Type II collagen quantification in experimental chondrogenesis
نویسندگان
چکیده
منابع مشابه
Autoimmunity to type II collagen an experimental model of arthritis
We have found that intradermal injection of native type II collagen extracted from human, chick or rat cartilage induces an inflammatory arthritis in approximately 40% of rats of several strains whether complete Freund's adjuvant or incomplete Freund's adjuvant is used. Type I or III collagen extracted from skin, cartilage proteoglycans and alpha1(II) chains were incapable of eliciting arthriti...
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Background: Lead is one of the sustainable metals with devastating effects on many tissues. This study, examined the adverse effect of lead poisoning on the gene expression of collagen type II and osteocalcin by mesenchymal stem cells (MSCs) cultured in chondrogenic and osteogenic media, respectively. Methods: We used 18 male Wistar rats, divided in 3 groups. In addition to libitum feed as the...
متن کاملType Ii Collagen - Induced Arthritis in Mice
The induction of immunological reactivity to type II collagen, a major component of cartilage, has recently been used to establish an experimental model of arthritis in the rat (1). Trentham and colleagues (1) have shown that the intradermal injection of collagen in Freund's complete or incomplete adjuvant elicits an arthritogenic reaction, specifically with native type II collagen. Arthritis o...
متن کاملSuppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.
Although oral administration of protein antigens may lead to specific immunologic unresponsiveness, this method of immunoregulation has not been applied to models of autoimmune disease. Type II collagen-induced arthritis is an animal model of polyarthritis induced in susceptible mice and rats by immunization with type II collagen, a major component of cartilage. Intragastric administration of s...
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INTRODUCTION: The use of human mesenchymal stem cells (hMSCs) induced toward chondrogenesis has been considered for regenerative therapies in load bearing tissues, such as articular cartilage or the intervertebral disc (IVD). Chondrocytes are enveloped by a pericellular matrix (PCM) consisting of hyaluronic acid, type VI collagen (ColVI) and proteoglycans such as decorin (Dcn). In order to eluc...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 1995
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(05)80054-8